Intranasal oxycodone self-administration in non-dependent opioid abusers.

A Comparative Study of Early Maladaptive Schemas and Impulsivity Between Opioid Abusers and Non-Abusers

Objective: The present study aimed to examine and compare early maladaptive schemas and impulsivity between opioid abusers and non-abusers. Methods: In this cross-sectional study, early maladaptive schemas and impulsivity were compared between 60 individuals dependent on opioids who were sampled from five drug rehabilitation centers in Qazvin and 60 workers of the Qazvin Glass Factory who were...

TITLE PAGE Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function

Background: Prescription opioid addiction is a significant health problem characterized by compulsive drug seeking, withdrawal and chronic relapse. We investigated the neurobiological consequences of escalation of prescription opioid use using extended access to intravenous oxycodone self-administration in rats. Methods: Male Wistar rats acquired oxycodone self-administration (0.15 mg/kg/infusi...

Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats

Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodone. Here, the vaccine's ability to prevent acquisition of intravenous (i.v.) oxycodone self-administration was studied in rats. Effects of vaccinati...

Intravenous buprenorphine self-administration by detoxified heroin abusers.

Several sources indicate that intravenously administered buprenorphine may have significant abuse liability in humans. The present study evaluated the reinforcing effects of intravenously administered buprenorphine (0, 2, and 8 mg) in detoxified heroin-dependent participants during a 7.5-week inpatient study. Participants (n = 6) were detoxified from heroin over a 1.5-week period immediately af...

Intranasal Opioid Compositions